Sunday, 22 February 2015


HIGH YIELD POINT FOR MICROBIOLOGY2015 important topics for DNB-CET, AIPGMEE, FMGE, DNB-PDCET, UPSC-CMS online medical examination .

Primary B-cell diseases include panhypogammaglobulinemia (Bruton disease), an X-linked deficiency of all three major classes of immunoglobulins, as well as other selective deficiencies of the immunoglobulins or their subgroups. This condition presents after 3 months of age (after maternal antibodies wane) with recurrent and often simultaneous bouts of otitis media, pneumonia, diarrhea, and sinusitis.

T-cell: Among the T-cell diseases is DiGeorge anomaly, in which defective embryologic development of the third and fourth pharyngeal pouches results in hypoplasia of both thymus and parathyroid glands. Associated findings with DiGeorge anomaly include CATCH: C for cardiac, A for abnormal faces, T for thymic hypoplasia, C for cleft palate, and H for hypocalcemia.

Combined B and T-cell diseases:
▪ X-linked recessive Wiskott-Aldrich syndrome of mild T-cell dysfunction, diminished serum IgM, marked elevation of IgA and IgE, eczema, recurrent middle-ear infections, lymphopenia, and thrombocytopenia.
▪ Severe combined immunodeficiency disease (SCID), have deficient T- and B-cells. Consequently, they are both marked lymphopenia and agammaglobulinemia, as well as hypoplasia of the thymus.
▪ Ataxia telangiectasia and chronic mucocutaneous candidiasis.